Causes of Kidney Failure

Causes of Kidney Failure


Renal disease is usually caused by some serious illness that gradually have an impact on the size of the organ damage that ranged in length from 10-13 centimeters and a thickness of 5 to 7. 5 centimeters.
There are several models of diseases that can affect kidney damage, including high blood pressure, diabetes mellitus, and blockage of the urinary tract. Obstruction of the urinary tract diseases such as stones, tumors, and narrowing also be a cause of kidney failure. Kidney failure can also be caused by autoimmune disorders, such as systemic lupus erythematosus.

Of all the causes of diseases, the greatest cause of diabetes mellitus. According to Budiman, 45 percent of people with kidney failure caused by diabetes mellitus, 28 percent of high blood pressure, 9 percent by glomerulonephritis, and 18 percent of other diseases
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Based on data from the United States Renal Data Sistem (USRDS), 2001, 45 percent of people with kidney failure caused by diabetes mellitus. Because the disease of diabetes mellitus including the most rapidly destroys the function of the cell. As many as 20-30 percent of diabetes patients mellitus model 1 and 2 diabetic nephropathy mengelami, namely impaired renal function due to leakage of blood membrane filter. Diabetes mellitus has become a cause of end-stage renal failure and causes one-third of patients undergoing hemodialysis.

Nevertheless, according to Budiman, not all people with diabetes will develop kidney failure. The main factor diabetics have kidney failure and is genetically less pressure to control blood sugar levels. The more often control blood sugar levels, the possibility of developing kidney failure will be reduced.

The mechanism of diabetes mellitus in kidney damage begins with high blood sugar reacts with proteins to momenually change the structure and function of cells, including the glomerulus. As a result, the protein barrier so damaged and leak protein into the urine.

Therefore, early detection needs to be done by measuring the levels of microalbuminuria is an early warning sistem of renal impairment. The urine protein is albumin excretion nan excess protein, albumin diluted with exretion rate of 30-300 mg/24jam, or can be measured with albumin- creatinine ratio from 2. 5 to 35 bersarnya mg/mmol in men, and 3. 5 to 35 mg/mmol in women.

Microalbuminuria is associated with the development of protesinuria by 60-80 percent. If it is not controlled, it can end up with kidney failure. But do not worry. Kidney failure can be prevented by keeping blood sugar within normal limits.